SSRI antidepressants are effective but can cause serotonin syndrome when mixed with certain drugs like tramadol, St. John’s wort, or MAOIs. Learn the real risks, warning signs, and how to stay safe.
Despite a 2006 FDA warning, research shows triptans and SSRIs together do not significantly increase serotonin syndrome risk. Evidence from large patient studies confirms the combination is safe for migraine sufferers on antidepressants.